The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
نویسندگان
چکیده
منابع مشابه
A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling
Spatial arrangement of neurite branching is instructed by both attractive and repulsive cues. Here we show that in C. elegans, the Wnt family of secreted glycoproteins specify neurite branching sites in the PLM mechanosensory neurons. Wnts function through MIG-1/Frizzled and the planar cell polarity protein (PCP) VANG-1/Strabismus/Vangl2 to restrict the formation of F-actin patches, which mark ...
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1. Abstract 2. Atypical, non-canonical pathways of Wnt-Frizzled signaling 3. Frizzled-2 as a G-protein-coupled receptor 4 Discovery of Gt alpha (transducin) expression in embryonic cells 5. Inhibition of Frizzled-2 signaling by inhibitors of cyclic GMP phosphodiesterase 6. Frizzled-2 regulates intracellular concentration of cyclic GMP 7. Inhibition of cyclic GMP phosphodiesterases blocks develo...
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The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic (beta)-catenin which, in association with transcription factors of the Lef/tcf fam...
متن کاملRack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
The vertebrate planar cell polarity (PCP) pathway shares molecular components with the β-catenin-mediated canonical Wnt pathway but acts through membrane complexes containing Vang or Frizzled to orient neighboring cells coordinately. The molecular interactions underlying the action of Vang in PCP signaling and specification, however, are yet to be delineated. Here, we report the identification ...
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The Wnt/Frizzled (FZD) signaling cascade is important for cell fate determination during embryonic development as well as maintaining tissue homeostasis in the adult. In addition to these physiologic roles, studies have shown that deregulation of Wnt/FZD signaling occurs during carcinogenesis. As an example, over 90% of the colorectal cancers have mutations in adenomatous polyposis coli (APC) o...
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ژورنال
عنوان ژورنال: Development
سال: 2018
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.168666